| Pair Name | Ginsenoside Rh2, Doxorubicin | ||
| Phytochemical Name | Ginsenoside Rh2 (PubChem CID: 119307 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Doxorubicin |
| Adverse Reactions | Nausea, vomiting, diarrhoea. This was inferred cold nature anticancer drug. |
| Recommendations | Hot: Ligusticum chuam; Angelica sinensis; Zingiber officinale; Panax ginseng; Pogostemon cablin |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Ginsenoside Rh2, Doxorubicin | |||
| Disease Info | [ICD-11:2D40] | Ehrlich's adenocarcinoma | Investigative | |
| Gene Regulation | Up-regulation | Expression | NFE2L2 | hsa4780 |
| In Vivo Model | CD-1 albino mice were inoculated intraperitoneally (i.p.) with 0.5 mL PBS containing 3×10⁶ cells of Ehrlich’s adenocarcinoma (cells were derived from 7-day-old tumor re-transplanted into CD-1 mice). | |||
| Result | Rh2-induced direct activation of Nrf2 might provide additional benefits by minimizing DOX toxicity towards non-cancerous cells. | |||
| No. | Title | Href |
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| 1 | Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2. Molecules. 2022 Jan 19;27(3):628. doi: 10.3390/molecules27030628. | Click |
